Well I have been going over this for some time to get Hybrid to work well with qtranslate, with a lot of help from Justin this is what I came up with. I am sure this will be improved upon….

You need to add this to your functions.php file in your child theme folder

add_filter( 'hybrid_meta_description', 'disable_stuff' );
add_filter( 'hybrid_meta_keywords', 'disable_stuff' );
add_action( 'hybrid_head', 'my_hybrid_meta_description' );
add_action( 'hybrid_head', 'my_hybrid_meta_keywords' );

function disable_stuff( $var ) {
	global $post;
			return false;
	}

function my_hybrid_meta_keywords() {
	global $wp_query;

if ( is_home() || is_front_page() ) {
		$keywords = __('your keywords with qtranslate quicktags');
		}

	/* If on a single post, check for custom field key Keywords and taxonomies. */
	elseif ( is_singular() && !is_preview() ) {
		$keywords = __(get_post_meta( $wp_query->post->ID, 'Keywords', true ));

		if ( empty( $keywords ) ) {
			$taxonomies = get_object_taxonomies( $wp_query->post->post_type );

			if ( is_array( $taxonomies ) ) {
				foreach ( $taxonomies as $tax ) {
					if ( $terms = get_the_term_list( $wp_query->post->ID, $tax, '', ', ', '' ) )
						$keywords[] = $terms;
				}
			}

			if ( !empty( $keywords ) )
				$keywords = join( ', ', $keywords );
		}
	}

	/* If we have keywords, join them together into one string and format for output. */
	if ( !empty( $keywords ) )
		$keywords = '' . "\n";

	echo apply_atomic( 'my_hybrid_meta_keywords', $keywords );
}

function my_hybrid_meta_description() {
	global $wp_query;
if ( is_home() || is_front_page() ) {
		$description = __('your frontpage description with qtranslate quicktags');
	}

	elseif ( is_singular() ) {
		$description = __(get_metadata( 'post', $wp_query->post->ID, 'Description', true ));

		if ( empty( $description ) && is_front_page() )
			$description = get_bloginfo( 'description' );

		elseif ( empty( $description ) )
			$description = __(get_post_field( 'post_excerpt', $wp_query->post->ID ));
	}

	elseif ( is_archive() ) {

		if ( is_author() )
			$description = get_the_author_meta( 'description', get_query_var( 'author' ) );

		elseif ( is_category() || is_tag() || is_tax() )
			$description = term_description( '', get_query_var( 'taxonomy' ) );
	}

	/* Format the meta description. */
	if ( !empty( $description ) )
		$description = '' . "\n";

	echo apply_atomic( 'my_hybrid_meta_description', $description );
}